• Potchefstroom was proclaimed on 22 December by the Voortrekker leader Andries Hendrik Potgieter. The town was originally at Oudedorp, approximately 10 km upstream from where the city is today.

• The town is relocated from Oudedorp to its current location.
• Potchefstroom became the capital of the Transvaal.
• First town magistrate appointed.

• First school.

• Postal service inaugurated between Lydenburg and Potchefstroom. The post was carried by post runners.
• Market started in Potchefstroom

• First church building (Nederduits Hervormde Church).

• First execution of a murderer.

• First gunpowder magazine built (still exists).
• Gold discovered in Potchefstroom district.

• First newspaper (De Staats Courant).
• First North Bridge built.

• First Postmaster appointed.

• New water furrow.
• New cemetery (second) laid out.

• Civil War between President Paul Kruger and usurper Stephanus Schoeman. Bombardment between them took place on the Bult.

• Swedish immigrants settled at Skandinawiëdrif.

• First Cricket club in Transvaal founded in Potchefstroom.

• Mail-coach service started between Pretoria and Potchefstroom.

• First mill opened.
• Potchefstroom had 275 houses and 1 200 inhabitants and is the largest town in Transvaal, the second largest town being Pretoria with 180 inhabitants.
• The second and current building of the Nederduitsche Hervormde Church was inaugurated.

• Gravel on streets.
• First agricultural show.
• First Reformed Church building and Dutch Reformed Church building inaugurated.
• First Anglican Church building inaugurated.

• First municipal elections.

• Theological School of the Reformed Church founded at Burgersdorp (later moved to Potchefstroom).

• First Methodist Church building.

• British troops annexed the Zuid Afrikaansche Republiek.
• First commercial bank, Standard Bank, opened.
• Black location, later Willem Klopperville, laid out south of town.

• First library service and museum movement.

• The Fort at Potchefstroom besieged. The 322 people in the Fort included a few civilians and British troops under Col Winslow. For 95 days they were confined to an area 25 X 25 metres and subsequently six people died. This was the first hostilities of the First Anglo-Boer War.

• Potchefstroom fell to the Boers.

• First Asians in Potchefstroom.

• First private post-boxes made available.

• Potchefstroom Stock Exchange founded.
• M L Fick Primary School, currently the oldest school, founded.

• First Rugby club in Transvaal founded.

• President Pretorius Primary School founded.

• A park with sporting fields, Alexandra Park, next to cemetery is developed.

• First tennis club in Transvaal founded in Potchefstroom.

• Second Dutch Reformed Church inaugurated. This building is the oldest DR Church across the Vaal River and was restored after a devastating fire in 2007.

• Landdrost-, Post-en Telegraafkantoor is office officially opened.

• Railroad between Potchefstroom and Johannesburg opened

• Anglo-Boer War declared

• British troops under General Sir Ian Hunter occupied Potchefstroom.
• Military hospital built.

• Health Committee formed to become first local authority after war.
• Church Street renamed King Edward Street and names of other streets changed.
• Experimental Farm founded.

• British Garrison housed approximately 1 000 soldiers in cantonments.
• Potchefstroom acquired municipal status
• First electrical power station came into operation.
• The Lyric Theatre opened on the corner of King Edward Street and Lombard Street.
• New cemetery (current) laid out.
•Two orphanages are combined. Out of this developed the Hoër Tegniese Skool.

• Potchefstroom town council held its first meeting.
• New Methodist Church opened in May.

• Theological School and Literary Department of the Reformed Church relocated to Potchefstroom from Burgersdorp.
• Potchefstroom High School for Boys founded.

• Railway line between Potchefstroom and Klerksdorp opened.

• Potchefstroom Herald newspaper founded.
• Building of Potchefstroom Dam started.
• First 40 telephones installed.
• New golf links officially opened, soon to become one of the best in South Africa.

• City Hall officially opened.
• Experimental Farm became an Agricultural School.

• New post-office and magistrate's office opened.
• Oak trees planted in Potchefstroom, the longest oak lane in South Africa. Later declared a National Monument.

• Municipality took over the supply of electricity.

• New electrical power station opened in Kock Street.
• On 14 July marathon runner K.K. McArthur, a Irish-born policeman from Potchefstroom, won a gold medal at the Olympic Games in Stockholm.

• Hospital opened.
• Municipal Library, funded by Carnegie, opened.
• British troops withdrew, but Potchefstroom stayed a military training base.

• Approximately 500 people died of Spanish Flu in Potchefstroom and district.

• New railway station opened in Potchefstroom.
• Potchefstroom University College founded after Literary Department parted ways with the Theological School.

• Synagogue opened.

• New artillery school opened at Potchefstroom military base.
• Witrand Rehabilitation Centre founded, second oldest psychiatric hospital in South Africa.

• Water purification service.
• Streets tarred.

• Railway opened between Potchefstroom and Fochville.

• Public swimming pool opened.

• Potchefstroom Centenary celebrations.
• New airfield inaugurated near Sewerage Farm.

• First Police station.
• Agriculture School became Agriculture College.
• Airfield moved to current location.

• Various street names changed. King Edward Street again became Church Street.

• Potchefstroom University College acquired full university status to become Potchefstroom University for Christian Higher Education.

• The National Gunners' Memorial was unveiled. It is also known as the National Artilelry Memorial. It is dedicated to all the Gunners who had laid down their lives for South Africa.

• Development of Ikageng started.

• Road between Klerksdorp and Potchefstroom tarred.

• Potchindustria laid out.

• Boskopdam built.

• Promosa laid out.

• Twelve people died in hail storm.
• Museum opened.

• Automated telephone services.

• Third and current Northbridge built.

• New post office opened in Potchefstroom (still in use).
• Military District upgraded to become Northwest Commando.

• Mohadin suburb laid out.
• Fire station opened in Newmarket Street.

• Twenty people died when an ammonia tank at the Triomf Fertiliser Plant exploded.

• Asian Shopping Centre opened.
• Potgieter Street widened to a double road.

• Self-governing body for Promosa.

• New prison opened at Mooibank.
• The Totius House Museum, part of the Theological School Complex, is officially opened as one of the house museums in Potchefstroom.

• The house of MW Pretorius former state president of the old ZAR was declared as a national monument and is now one of three house museums in Potchefstroom.

• New Library and museum building inaugurated.

• Self-governing body for Ikageng.

• Self-governing body for Mohadin.

• The Goetz-Fleischack House on the corner of Nelson Mandela and Sol Plaatjes Avenue is declared a National Monument. It is the only example of an early town house still in existence and is fitted out as a house museum.

• Pick 'n Pay Shopping Centre opened.

• 150 Year Celebrations.
•AH Potgieter Banqueting Halls opened. Later renamed Madiba Banqueting Halls.

• First private hospital opened (MediCity – later MediClinic).

• Ikageng riots.

• New Police Office.

• Air Force base closed.

• First national democratic elections – ANC won Potchefstroom with a 59.08% vote
• Potchefstroom acquired city status.

• New fire station opened in Potchindustria.

• Cachet Park Shopping Centre developed.

• Checkers Centre enlarged and renamed Riverwalk Centre.

• First Aardklop National Art Festival.

• Centenary celebrations of the Anglo Boer War.

• PU for CHO became the North West University, Potchefstroom Campus after merger with University of Bophuthatswana.
• 3 Students died of Meningitis.

• Wide ranging street name changes.

• The Vredefort Dome, the biggest and oldest meteorite impact site in the world was declared a World Heritage Site.

• Potchefstroom Municipality became Tlokwe Municipality.

• Kynoch Fertiliser Plant, previously known as Triomf, closed.
• The Dutch Reformed Church in Nelson Mandela Drive is destroyed by a fire due to an electrical fault. By 2011 the church is fully restored and inaugurated.

• Mooiriver Mall opens.
• Herald newspaper celebrates centenary.

• Potchefstroom hosts the Spanish soccer team during the World Soccer Cup.
• Sports Village opened.

• It is announced that a velodrome will be built in Potchefstroom. In 2012 it is announced that it will be built near the Potchefstroom Dam. It will have a track of 250 meter and seating for 3 000 to 4 000.